Drug interactions
Remifentanil + Suvorexant
Severity: Moderate
Remifentanil and Suvorexant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the CNS, so together they increase sedation and impair psychomotor function. Next-day drowsiness may result.
What this interaction means in plain words
Remifentanil and Suvorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Remifentanil belongs to Musculoskeletal; Suvorexant belongs to Central Nervous System.
Why it happens
Additive CNS depression from an opioid and an orexin receptor antagonist.
What to do
Use the lowest effective doses and monitor sedation and breathing. Adjust the suvorexant dose if excessive sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Remifentanil
- Alvimopan + Remifentanil Contraindicated
- Isocarboxazid + Remifentanil Contraindicated
- Olanzapine / samidorphan + Remifentanil Contraindicated
- Phenelzine + Remifentanil Contraindicated
- Benzhydrocodone / acetaminophen + Remifentanil Major
- Brexanolone + Remifentanil Major
Other interactions of Suvorexant
Frequently asked questions
Can I take Remifentanil with Suvorexant?
MediHelp rates the interaction as moderate. Remifentanil and Suvorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the CNS, so together they increase sedation and impair psychomotor function. Next-day drowsiness may result.
How serious is the interaction between Remifentanil and Suvorexant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation and breathing. Adjust the suvorexant dose if excessive sedation occurs.
What other medicines interact with Remifentanil?
MediHelp also lists interactions of Remifentanil with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Remifentanil page.
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