Drug interactions
Reteplase + Tolmetin
Severity: Major
Reteplase and Tolmetin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Reteplase is a thrombolytic that markedly raises bleeding risk, and NSAIDs impair platelet function and can cause gastrointestinal lesions. Together they may increase the likelihood of serious hemorrhage.
What this interaction means in plain words
Reteplase and Tolmetin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Thrombolysis combined with NSAID-induced platelet inhibition produces additive impairment of hemostasis.
What to do
Avoid starting tolmetin around thrombolytic therapy and use alternative analgesia. Monitor closely for bleeding, including intracranial and gastrointestinal sites.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Frequently asked questions
Can I take Reteplase with Tolmetin?
MediHelp rates the interaction as major. Reteplase and Tolmetin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Reteplase is a thrombolytic that markedly raises bleeding risk, and NSAIDs impair platelet function and can cause gastrointestinal lesions. Together they may increase the likelihood of serious hemorrhage.
How serious is the interaction between Reteplase and Tolmetin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid starting tolmetin around thrombolytic therapy and use alternative analgesia. Monitor closely for bleeding, including intracranial and gastrointestinal sites.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Tolmetin page.
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