Drug interactions
Rifampin + Ropinirole
Severity: Moderate
Rifampin and Ropinirole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampin is a potent enzyme inducer and may lower ropinirole concentrations, risking loss of symptom control during treatment.
What this interaction means in plain words
Rifampin and Ropinirole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Rifampin induces CYP1A2 and other CYP enzymes, accelerating ropinirole metabolism.
What to do
Monitor clinical response and increase the ropinirole dose if needed. Reduce it after rifampin is stopped, as induction wanes over weeks.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ropinirole
- Amisulpride + Ropinirole Contraindicated
- Chlorpromazine + Ropinirole Major
- Droperidol + Ropinirole Major
- Fluphenazine + Ropinirole Major
- Fluvoxamine + Ropinirole Major
- Haloperidol + Ropinirole Major
Frequently asked questions
Can I take Rifampin with Ropinirole?
MediHelp rates the interaction as moderate. Rifampin and Ropinirole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifampin is a potent enzyme inducer and may lower ropinirole concentrations, risking loss of symptom control during treatment.
How serious is the interaction between Rifampin and Ropinirole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and increase the ropinirole dose if needed. Reduce it after rifampin is stopped, as induction wanes over weeks.
What other medicines interact with Ropinirole?
MediHelp also lists interactions of Ropinirole with, for example, Amisulpride, Chlorpromazine, Droperidol. The full list is on the Ropinirole page.
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