Drug interactions
Rifampin + Sacubitril-valsartan
Severity: Moderate
Rifampin and Sacubitril-valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampin inhibits OATP1B1 on a single-dose basis and valsartan exposure may rise with transporter inhibition, though chronic rifampin induction may offset this. The net clinical effect is uncertain and probably modest.
What this interaction means in plain words
Rifampin and Sacubitril-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Rifampin inhibits hepatic uptake transporters (OATP1B1/1B3), which can raise valsartan exposure.
What to do
Monitor blood pressure, renal function and potassium when rifampin is started or stopped; adjust the sacubitril-valsartan dose if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Frequently asked questions
Can I take Rifampin with Sacubitril-valsartan?
MediHelp rates the interaction as moderate. Rifampin and Sacubitril-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifampin inhibits OATP1B1 on a single-dose basis and valsartan exposure may rise with transporter inhibition, though chronic rifampin induction may offset this. The net clinical effect is uncertain and probably modest.
How serious is the interaction between Rifampin and Sacubitril-valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and potassium when rifampin is started or stopped; adjust the sacubitril-valsartan dose if hypotension occurs.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
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