Drug interactions
Rifampin + Selegiline
Severity: Moderate
Rifampin and Selegiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampin is a strong inducer of metabolizing enzymes and may lower selegiline concentrations, which are partly cleared by CYP2B6 and CYP3A4. This may reduce the clinical effect of selegiline.
What this interaction means in plain words
Rifampin and Selegiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP2B6 and CYP3A4 by rifampin, increasing selegiline metabolism.
What to do
Monitor for loss of efficacy and adjust the selegiline dose if needed. Reassess when rifampin is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Frequently asked questions
Can I take Rifampin with Selegiline?
MediHelp rates the interaction as moderate. Rifampin and Selegiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifampin is a strong inducer of metabolizing enzymes and may lower selegiline concentrations, which are partly cleared by CYP2B6 and CYP3A4. This may reduce the clinical effect of selegiline.
How serious is the interaction between Rifampin and Selegiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of efficacy and adjust the selegiline dose if needed. Reassess when rifampin is stopped.
What other medicines interact with Selegiline?
MediHelp also lists interactions of Selegiline with, for example, Amitriptyline, Amoxapine, Atomoxetine. The full list is on the Selegiline page.
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