Drug interactions
Rifampin + Tolterodine
Severity: Moderate
Rifampin and Tolterodine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampin induces CYP3A4 and lowers tolterodine concentrations, though the active metabolite and total active moiety are affected less. Bladder symptom control may decline.
What this interaction means in plain words
Rifampin and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP3A4 by rifampin increases tolterodine clearance.
What to do
Monitor for reduced symptom control and increase the tolterodine dose or switch agents if efficacy is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolterodine
Frequently asked questions
Can I take Rifampin with Tolterodine?
MediHelp rates the interaction as moderate. Rifampin and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifampin induces CYP3A4 and lowers tolterodine concentrations, though the active metabolite and total active moiety are affected less. Bladder symptom control may decline.
How serious is the interaction between Rifampin and Tolterodine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced symptom control and increase the tolterodine dose or switch agents if efficacy is lost.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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