Drug interactions
Rifampin + Trandolapril
Severity: Minor
Rifampin and Trandolapril: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampin may lower exposure to the active metabolite of trandolapril, potentially weakening its blood pressure lowering effect. The clinical effect is expected to be small and is poorly documented.
What this interaction means in plain words
Rifampin and Trandolapril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Rifampin induces esterases and other metabolic pathways, which may alter the activation and clearance of trandolapril, but the mechanism is not firmly established.
What to do
No routine change is needed. Check blood pressure when rifampin is started or stopped and adjust the trandolapril dose if control is lost.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Trandolapril
- Aliskiren + Trandolapril Contraindicated
- Protein a column + Trandolapril Contraindicated
- Sacubitril / valsartan + Trandolapril Contraindicated
- Sacubitril-valsartan + Trandolapril Contraindicated
- Aldesleukin + Trandolapril Major
- Amifostine + Trandolapril Major
Frequently asked questions
Can I take Rifampin with Trandolapril?
MediHelp rates the interaction as minor. Rifampin and Trandolapril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rifampin may lower exposure to the active metabolite of trandolapril, potentially weakening its blood pressure lowering effect. The clinical effect is expected to be small and is poorly documented.
How serious is the interaction between Rifampin and Trandolapril?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Check blood pressure when rifampin is started or stopped and adjust the trandolapril dose if control is lost.
What other medicines interact with Trandolapril?
MediHelp also lists interactions of Trandolapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Trandolapril page.
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