Drug interactions
Rifampin + Vinorelbine
Severity: Moderate
Rifampin and Vinorelbine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampin strongly induces CYP3A4, which metabolizes vinorelbine. Exposure to vinorelbine may fall, potentially reducing its antitumor effect.
What this interaction means in plain words
Rifampin and Vinorelbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Rifampin induction of CYP3A4 (and P-gp) increases vinorelbine clearance.
What to do
Use an alternative to rifampin when possible. If the combination is unavoidable, monitor for reduced treatment response and for toxicity if rifampin is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vinorelbine
Frequently asked questions
Can I take Rifampin with Vinorelbine?
MediHelp rates the interaction as moderate. Rifampin and Vinorelbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifampin strongly induces CYP3A4, which metabolizes vinorelbine. Exposure to vinorelbine may fall, potentially reducing its antitumor effect.
How serious is the interaction between Rifampin and Vinorelbine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative to rifampin when possible. If the combination is unavoidable, monitor for reduced treatment response and for toxicity if rifampin is stopped.
What other medicines interact with Vinorelbine?
MediHelp also lists interactions of Vinorelbine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Belatacept. The full list is on the Vinorelbine page.
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