Drug interactions
Rifaximin + Sotorasib
Severity: Moderate
Rifaximin and Sotorasib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotorasib is a P-glycoprotein inhibitor and can raise the exposure of P-gp substrates. Rifaximin is a P-gp substrate, so its systemic levels may rise. This matters most when hepatic impairment already increases rifaximin exposure.
What this interaction means in plain words
Rifaximin and Sotorasib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rifaximin belongs to Anti Bacterial; Sotorasib belongs to Oncology.
Why it happens
Sotorasib inhibits P-glycoprotein efflux, which raises rifaximin absorption and systemic exposure.
What to do
Monitor for rifaximin adverse effects, particularly in patients with hepatic impairment. Consider a lower rifaximin exposure strategy or an alternative if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rifaximin
- Cholera vaccine + Rifaximin Major
- Microbiota + Rifaximin Major
- Amiodarone + Rifaximin Moderate
- Bcg intravesical live + Rifaximin Moderate
- Cyclosporine + Rifaximin Moderate
- Cyclosporin + Rifaximin Moderate
Other interactions of Sotorasib
- Amobarbital + Sotorasib Major
- Apalutamide + Sotorasib Major
- Carbamazepine + Sotorasib Major
- Colchicine + Sotorasib Major
- Cyclosporin + Sotorasib Major
- Digoxin + Sotorasib Major
Frequently asked questions
Can I take Rifaximin with Sotorasib?
MediHelp rates the interaction as moderate. Rifaximin and Sotorasib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sotorasib is a P-glycoprotein inhibitor and can raise the exposure of P-gp substrates. Rifaximin is a P-gp substrate, so its systemic levels may rise. This matters most when hepatic impairment already increases rifaximin exposure.
How serious is the interaction between Rifaximin and Sotorasib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for rifaximin adverse effects, particularly in patients with hepatic impairment. Consider a lower rifaximin exposure strategy or an alternative if toxicity appears.
What other medicines interact with Rifaximin?
MediHelp also lists interactions of Rifaximin with, for example, Cholera vaccine, Microbiota, Amiodarone. The full list is on the Rifaximin page.
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