Drug interactions
Nitroglycerin + Riociguat
Severity: Contraindicated
Nitroglycerin and Riociguat: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Riociguat stimulates soluble guanylate cyclase and nitrates supply nitric oxide, producing additive vasodilation. Severe, potentially life-threatening hypotension can result. Labeling contraindicates concomitant use of riociguat with nitrates in any form.
What this interaction means in plain words
Nitroglycerin and Riociguat are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Nitroglycerin belongs to Cardiovascular; Riociguat belongs to Cardiovascular.
Why it happens
Additive cGMP-mediated vasodilation from nitric oxide donation and soluble guanylate cyclase stimulation.
What to do
Do not co-administer. Use a non-nitrate option for angina or acute needs while on riociguat.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Nitroglycerin
- Avanafil + Nitroglycerin Contraindicated
- Nitroglycerin + Sildenafil Contraindicated
- Nitroglycerin + Tadalafil Contraindicated
- Nitroglycerin + Vardenafil Contraindicated
- Dihydroergotamine intranasal + Nitroglycerin Major
- Dihydroergotamine + Nitroglycerin Major
Other interactions of Riociguat
- Avanafil + Riociguat Contraindicated
- Dipyridamole + Riociguat Contraindicated
- Isosorbide dinitrate + Riociguat Contraindicated
- Isosorbide mononitrate + Riociguat Contraindicated
- Riociguat + Sildenafil Contraindicated
- Riociguat + Tadalafil Contraindicated
Frequently asked questions
Can I take Nitroglycerin with Riociguat?
MediHelp rates the interaction as contraindicated. Nitroglycerin and Riociguat are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Riociguat stimulates soluble guanylate cyclase and nitrates supply nitric oxide, producing additive vasodilation. Severe, potentially life-threatening hypotension can result. Labeling contraindicates concomitant use of riociguat with nitrates in any form.
How serious is the interaction between Nitroglycerin and Riociguat?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer. Use a non-nitrate option for angina or acute needs while on riociguat.
What other medicines interact with Nitroglycerin?
MediHelp also lists interactions of Nitroglycerin with, for example, Avanafil, Sildenafil, Tadalafil. The full list is on the Nitroglycerin page.
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