Drug interactions
Rivastigmine + Timolol
Severity: Moderate
Rivastigmine and Timolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rivastigmine increases cholinergic tone and can slow the heart rate, and timolol adds beta-blockade. The combination may cause bradycardia, syncope and heart block.
What this interaction means in plain words
Rivastigmine and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rivastigmine belongs to Central Nervous System; Timolol belongs to Cardiovascular.
Why it happens
Additive bradycardic effects from cholinesterase inhibition (vagotonic) and beta-adrenergic blockade.
What to do
Monitor heart rate and watch for dizziness or syncope, especially after dose increases. Reduce or stop one agent if symptomatic bradycardia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Timolol
- Acebutolol + Timolol Major
- Albuterol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
Other interactions of Rivastigmine
Frequently asked questions
Can I take Rivastigmine with Timolol?
MediHelp rates the interaction as moderate. Rivastigmine and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rivastigmine increases cholinergic tone and can slow the heart rate, and timolol adds beta-blockade. The combination may cause bradycardia, syncope and heart block.
How serious is the interaction between Rivastigmine and Timolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and watch for dizziness or syncope, especially after dose increases. Reduce or stop one agent if symptomatic bradycardia occurs.
What other medicines interact with Timolol?
MediHelp also lists interactions of Timolol with, for example, Acebutolol, Albuterol, Aldesleukin. The full list is on the Timolol page.
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