Drug interactions
Rocuronium + Sufentanil sl
Severity: Moderate
Rocuronium and Sufentanil sl: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sufentanil adds respiratory depression and sedation to rocuronium paralysis. This is manageable with controlled ventilation but hazardous if ventilation is not assured or residual blockade persists.
What this interaction means in plain words
Rocuronium and Sufentanil sl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive respiratory compromise from central opioid depression and peripheral neuromuscular blockade.
What to do
Use only where ventilation can be controlled, and monitor oxygenation and train-of-four. Avoid sublingual sufentanil in non-ventilated patients during neuromuscular blockade.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rocuronium
Frequently asked questions
Can I take Rocuronium with Sufentanil sl?
MediHelp rates the interaction as moderate. Rocuronium and Sufentanil sl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sufentanil adds respiratory depression and sedation to rocuronium paralysis. This is manageable with controlled ventilation but hazardous if ventilation is not assured or residual blockade persists.
How serious is the interaction between Rocuronium and Sufentanil sl?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only where ventilation can be controlled, and monitor oxygenation and train-of-four. Avoid sublingual sufentanil in non-ventilated patients during neuromuscular blockade.
What other medicines interact with Rocuronium?
MediHelp also lists interactions of Rocuronium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin. The full list is on the Rocuronium page.
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