Drug interactions
Romidepsin + Telavancin
Severity: Moderate
Romidepsin and Telavancin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Romidepsin can cause ECG changes including QT prolongation, and telavancin may add to the effect. The combination may increase the risk of arrhythmia, particularly with electrolyte disturbances.
What this interaction means in plain words
Romidepsin and Telavancin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic effects on cardiac repolarization.
What to do
Check a baseline ECG and correct potassium and magnesium before combining. Monitor the ECG during therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Telavancin
- Telavancin + Thioridazine Contraindicated
- Adagrasib + Telavancin Major
- Amiodarone + Telavancin Major
- Amisulpride + Telavancin Major
- Anagrelide + Telavancin Major
- Arsenic trioxide + Telavancin Major
Frequently asked questions
Can I take Romidepsin with Telavancin?
MediHelp rates the interaction as moderate. Romidepsin and Telavancin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Romidepsin can cause ECG changes including QT prolongation, and telavancin may add to the effect. The combination may increase the risk of arrhythmia, particularly with electrolyte disturbances.
How serious is the interaction between Romidepsin and Telavancin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and correct potassium and magnesium before combining. Monitor the ECG during therapy.
What other medicines interact with Telavancin?
MediHelp also lists interactions of Telavancin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Telavancin page.
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