Drug interactions
Romidepsin + Trastuzumab
Severity: Moderate
Romidepsin and Trastuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Romidepsin can cause neutropenia and thrombocytopenia. With trastuzumab, neutropenia and infection risk may be increased.
What this interaction means in plain words
Romidepsin and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive myelosuppression.
What to do
Monitor complete blood counts and for infection. Adjust romidepsin dosing for significant cytopenias.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trastuzumab
Frequently asked questions
Can I take Romidepsin with Trastuzumab?
MediHelp rates the interaction as moderate. Romidepsin and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Romidepsin can cause neutropenia and thrombocytopenia. With trastuzumab, neutropenia and infection risk may be increased.
How serious is the interaction between Romidepsin and Trastuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts and for infection. Adjust romidepsin dosing for significant cytopenias.
What other medicines interact with Trastuzumab?
MediHelp also lists interactions of Trastuzumab with, for example, Daunorubicin, Doxorubicin liposomal, Doxorubicin. The full list is on the Trastuzumab page.
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