Drug interactions
Ropeginterferon alfa 2b + Sulphasalazine
Severity: Moderate
Ropeginterferon alfa 2b and Sulphasalazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Interferons can suppress bone marrow, and sulfasalazine can cause leukopenia, agranulocytosis and other cytopenias. Combining them may lead to additive myelosuppression.
What this interaction means in plain words
Ropeginterferon alfa 2b and Sulphasalazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive bone marrow suppression.
What to do
Monitor complete blood counts regularly, particularly early in therapy. Reduce or interrupt either drug if significant cytopenias occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulphasalazine
- Deferiprone + Sulphasalazine Major
- Pexidartinib + Sulphasalazine Major
- Sepiapterin + Sulphasalazine Major
- Acalabrutinib + Sulphasalazine Moderate
- Aceclofenac + Sulphasalazine Moderate
- Acetazolamide + Sulphasalazine Moderate
Frequently asked questions
Can I take Ropeginterferon alfa 2b with Sulphasalazine?
MediHelp rates the interaction as moderate. Ropeginterferon alfa 2b and Sulphasalazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Interferons can suppress bone marrow, and sulfasalazine can cause leukopenia, agranulocytosis and other cytopenias. Combining them may lead to additive myelosuppression.
How serious is the interaction between Ropeginterferon alfa 2b and Sulphasalazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts regularly, particularly early in therapy. Reduce or interrupt either drug if significant cytopenias occur.
What other medicines interact with Sulphasalazine?
MediHelp also lists interactions of Sulphasalazine with, for example, Deferiprone, Pexidartinib, Sepiapterin. The full list is on the Sulphasalazine page.
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