Drug interactions
Ropinirole + Smoking
Severity: Moderate
Ropinirole and Smoking: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cigarette smoking induces CYP1A2, and smokers have lower ropinirole exposure. Higher doses may be needed in smokers, and stopping smoking can raise levels and cause adverse effects.
What this interaction means in plain words
Ropinirole and Smoking can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Polycyclic aromatic hydrocarbons in smoke induce CYP1A2, increasing ropinirole clearance.
What to do
Titrate ropinirole to response in smokers. Monitor for nausea, somnolence and hypotension and consider dose reduction if the patient quits smoking.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ropinirole
- Amisulpride + Ropinirole Contraindicated
- Chlorpromazine + Ropinirole Major
- Droperidol + Ropinirole Major
- Fluphenazine + Ropinirole Major
- Fluvoxamine + Ropinirole Major
- Haloperidol + Ropinirole Major
Frequently asked questions
Can I take Ropinirole with Smoking?
MediHelp rates the interaction as moderate. Ropinirole and Smoking can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cigarette smoking induces CYP1A2, and smokers have lower ropinirole exposure. Higher doses may be needed in smokers, and stopping smoking can raise levels and cause adverse effects.
How serious is the interaction between Ropinirole and Smoking?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate ropinirole to response in smokers. Monitor for nausea, somnolence and hypotension and consider dose reduction if the patient quits smoking.
What other medicines interact with Ropinirole?
MediHelp also lists interactions of Ropinirole with, for example, Amisulpride, Chlorpromazine, Droperidol. The full list is on the Ropinirole page.
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