Drug interactions
Sacubitril-valsartan + Salicylates
Severity: Minor
Sacubitril-valsartan and Salicylates: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Non-acetylated salicylates can have mild effects on renal prostaglandins and may reduce renal function or blunt antihypertensive effect, though less than conventional NSAIDs. Potassium and creatinine may rise in vulnerable patients.
What this interaction means in plain words
Sacubitril-valsartan and Salicylates have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak inhibition of renal prostaglandin synthesis can reduce renal perfusion and sodium excretion.
What to do
Monitor renal function and potassium in elderly or volume-depleted patients, and use the lowest effective salicylate dose.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Frequently asked questions
Can I take Sacubitril-valsartan with Salicylates?
MediHelp rates the interaction as minor. Sacubitril-valsartan and Salicylates have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Non-acetylated salicylates can have mild effects on renal prostaglandins and may reduce renal function or blunt antihypertensive effect, though less than conventional NSAIDs. Potassium and creatinine may rise in vulnerable patients.
How serious is the interaction between Sacubitril-valsartan and Salicylates?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and potassium in elderly or volume-depleted patients, and use the lowest effective salicylate dose.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
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