Drug interactions
Sacubitril / valsartan + Salmeterol
Severity: Minor
Sacubitril / valsartan and Salmeterol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salmeterol can lower serum potassium while sacubitril/valsartan can raise it, so the effects are opposing and clinically minor. No significant interaction is expected at usual doses.
What this interaction means in plain words
Sacubitril / valsartan and Salmeterol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing effects on serum potassium: beta-2 agonism shifts potassium into cells while angiotensin receptor blockade reduces its excretion.
What to do
No specific action beyond routine potassium monitoring in patients on sacubitril/valsartan.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Frequently asked questions
Can I take Sacubitril / valsartan with Salmeterol?
MediHelp rates the interaction as minor. Sacubitril / valsartan and Salmeterol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Salmeterol can lower serum potassium while sacubitril/valsartan can raise it, so the effects are opposing and clinically minor. No significant interaction is expected at usual doses.
How serious is the interaction between Sacubitril / valsartan and Salmeterol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action beyond routine potassium monitoring in patients on sacubitril/valsartan.
What other medicines interact with Salmeterol?
MediHelp also lists interactions of Salmeterol with, for example, Ritonavir, Saquinavir, Amitriptyline. The full list is on the Salmeterol page.
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