Drug interactions
Sacubitril-valsartan + Salsalate
Severity: Moderate
Sacubitril-valsartan and Salsalate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salsalate is a salicylate NSAID with weak prostaglandin inhibition, but it may still reduce renal function and blunt the antihypertensive effect of sacubitril-valsartan. Hyperkalemia and acute kidney injury are possible, especially in older or volume-depleted patients.
What this interaction means in plain words
Sacubitril-valsartan and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of renal prostaglandin synthesis reduces renal perfusion and sodium excretion, compounding the renal effects of angiotensin receptor blockade.
What to do
Use the lowest effective dose for the shortest time and monitor creatinine, potassium and blood pressure. Consider paracetamol as an alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Frequently asked questions
Can I take Sacubitril-valsartan with Salsalate?
MediHelp rates the interaction as moderate. Sacubitril-valsartan and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salsalate is a salicylate NSAID with weak prostaglandin inhibition, but it may still reduce renal function and blunt the antihypertensive effect of sacubitril-valsartan. Hyperkalemia and acute kidney injury are possible, especially in older or volume-depleted patients.
How serious is the interaction between Sacubitril-valsartan and Salsalate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective dose for the shortest time and monitor creatinine, potassium and blood pressure. Consider paracetamol as an alternative.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
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