Drug interactions
Sacubitril-valsartan + Saquinavir
Severity: Minor
Sacubitril-valsartan and Saquinavir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valsartan is taken up into the liver by OATP1B1 and inhibitors may increase its exposure. Saquinavir may inhibit this transporter, so a small increase in valsartan effect is possible, with potential hypotension or hyperkalemia.
What this interaction means in plain words
Sacubitril-valsartan and Saquinavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible inhibition of OATP1B1-mediated hepatic uptake of valsartan.
What to do
No dose change is routinely needed; monitor blood pressure and renal function when saquinavir is started or stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Frequently asked questions
Can I take Sacubitril-valsartan with Saquinavir?
MediHelp rates the interaction as minor. Sacubitril-valsartan and Saquinavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Valsartan is taken up into the liver by OATP1B1 and inhibitors may increase its exposure. Saquinavir may inhibit this transporter, so a small increase in valsartan effect is possible, with potential hypotension or hyperkalemia.
How serious is the interaction between Sacubitril-valsartan and Saquinavir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is routinely needed; monitor blood pressure and renal function when saquinavir is started or stopped.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
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