Drug interactions
Sacubitril-valsartan + Sodium sulfate / ?magnesium sulfate / potassium chloride
Severity: Moderate
Sacubitril-valsartan and Sodium sulfate / ?magnesium sulfate / potassium chloride: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bowel preparation causes fluid loss and electrolyte shifts, and volume depletion with angiotensin receptor blockade increases the risk of acute kidney injury and hypotension. The potassium content adds to hyperkalemia risk in vulnerable patients.
What this interaction means in plain words
Sacubitril-valsartan and Sodium sulfate / ?magnesium sulfate / potassium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Volume depletion reduces renal perfusion in the presence of RAAS blockade, and the potassium load adds to reduced renal potassium excretion.
What to do
Consider withholding sacubitril-valsartan on the day of bowel preparation in at-risk patients, ensure adequate oral hydration, and check renal function and electrolytes if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Frequently asked questions
Can I take Sacubitril-valsartan with Sodium sulfate / ?magnesium sulfate / potassium chloride?
MediHelp rates the interaction as moderate. Sacubitril-valsartan and Sodium sulfate / ?magnesium sulfate / potassium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bowel preparation causes fluid loss and electrolyte shifts, and volume depletion with angiotensin receptor blockade increases the risk of acute kidney injury and hypotension. The potassium content adds to hyperkalemia risk in vulnerable patients.
How serious is the interaction between Sacubitril-valsartan and Sodium sulfate / ?magnesium sulfate / potassium chloride?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider withholding sacubitril-valsartan on the day of bowel preparation in at-risk patients, ensure adequate oral hydration, and check renal function and electrolytes if symptoms develop.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
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