Drug interactions
Sacubitril-valsartan + Sulfasalazine
Severity: Minor
Sacubitril-valsartan and Sulfasalazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfasalazine is not a typical NSAID and has little effect on renal prostaglandins, so a meaningful interaction with sacubitril-valsartan is not well established. The legacy concerns are largely based on NSAID class effects that do not clearly apply.
What this interaction means in plain words
Sacubitril-valsartan and Sulfasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
No established mechanism; NSAID-like renal effects are not expected with sulfasalazine.
What to do
No specific action needed beyond routine monitoring of renal function and potassium during sacubitril-valsartan therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Frequently asked questions
Can I take Sacubitril-valsartan with Sulfasalazine?
MediHelp rates the interaction as minor. Sacubitril-valsartan and Sulfasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sulfasalazine is not a typical NSAID and has little effect on renal prostaglandins, so a meaningful interaction with sacubitril-valsartan is not well established. The legacy concerns are largely based on NSAID class effects that do not clearly apply.
How serious is the interaction between Sacubitril-valsartan and Sulfasalazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action needed beyond routine monitoring of renal function and potassium during sacubitril-valsartan therapy.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
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