Drug interactions
Sacubitril-valsartan + Synthetic human angiotensin ii
Severity: Moderate
Sacubitril-valsartan and Synthetic human angiotensin ii: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valsartan blocks the AT1 receptor, so the pressor effect of exogenous angiotensin II may be reduced. This can lead to a diminished response in patients with vasodilatory shock who are taking an angiotensin receptor blocker.
What this interaction means in plain words
Sacubitril-valsartan and Synthetic human angiotensin ii can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism at the angiotensin II type 1 receptor by valsartan.
What to do
Hold sacubitril-valsartan in patients receiving angiotensin II for shock, and titrate the angiotensin II dose to blood pressure response, noting that higher doses may be needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Frequently asked questions
Can I take Sacubitril-valsartan with Synthetic human angiotensin ii?
MediHelp rates the interaction as moderate. Sacubitril-valsartan and Synthetic human angiotensin ii can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valsartan blocks the AT1 receptor, so the pressor effect of exogenous angiotensin II may be reduced. This can lead to a diminished response in patients with vasodilatory shock who are taking an angiotensin receptor blocker.
How serious is the interaction between Sacubitril-valsartan and Synthetic human angiotensin ii?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Hold sacubitril-valsartan in patients receiving angiotensin II for shock, and titrate the angiotensin II dose to blood pressure response, noting that higher doses may be needed.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
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