Drug interactions
Sacubitril-valsartan + Terbutaline
Severity: Minor
Sacubitril-valsartan and Terbutaline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Terbutaline shifts potassium into cells and can cause hypokalemia, whereas sacubitril-valsartan tends to raise potassium. The effects partly oppose, so net potassium change is unpredictable, and terbutaline may also cause tachycardia and lower diastolic pressure.
What this interaction means in plain words
Sacubitril-valsartan and Terbutaline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Sacubitril-valsartan belongs to Cardiovascular; Terbutaline belongs to Respiratory.
Why it happens
Opposing effects on serum potassium: beta-2 agonist cellular uptake versus reduced renal excretion from RAAS blockade.
What to do
No routine change is required; check potassium in patients using high-dose or repeated terbutaline, or with renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Other interactions of Terbutaline
Frequently asked questions
Can I take Sacubitril-valsartan with Terbutaline?
MediHelp rates the interaction as minor. Sacubitril-valsartan and Terbutaline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Terbutaline shifts potassium into cells and can cause hypokalemia, whereas sacubitril-valsartan tends to raise potassium. The effects partly oppose, so net potassium change is unpredictable, and terbutaline may also cause tachycardia and lower diastolic pressure.
How serious is the interaction between Sacubitril-valsartan and Terbutaline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is required; check potassium in patients using high-dose or repeated terbutaline, or with renal impairment.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
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