Drug interactions
Sacubitril / valsartan + Timolol
Severity: Moderate
Sacubitril / valsartan and Timolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs lower blood pressure, so combined use may cause additive hypotension. Valsartan can raise potassium, and beta-blockers may contribute modestly to hyperkalemia. Sacubitril/valsartan is also contraindicated in pregnancy because of fetal toxicity.
What this interaction means in plain words
Sacubitril / valsartan and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive blood pressure lowering, with angiotensin receptor blockade and beta-blockade both tending to raise serum potassium.
What to do
Monitor blood pressure, serum potassium and renal function after starting or adjusting either drug. The combination is standard in heart failure and is generally used with monitoring.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Timolol
- Acebutolol + Timolol Major
- Albuterol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
Frequently asked questions
Can I take Sacubitril / valsartan with Timolol?
MediHelp rates the interaction as moderate. Sacubitril / valsartan and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs lower blood pressure, so combined use may cause additive hypotension. Valsartan can raise potassium, and beta-blockers may contribute modestly to hyperkalemia. Sacubitril/valsartan is also contraindicated in pregnancy because of fetal toxicity.
How serious is the interaction between Sacubitril / valsartan and Timolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum potassium and renal function after starting or adjusting either drug. The combination is standard in heart failure and is generally used with monitoring.
What other medicines interact with Timolol?
MediHelp also lists interactions of Timolol with, for example, Acebutolol, Albuterol, Aldesleukin. The full list is on the Timolol page.
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