Drug interactions
Sacubitril-valsartan + Xipamide
Severity: Moderate
Sacubitril-valsartan and Xipamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Xipamide is a thiazide-like diuretic that lowers blood pressure and intravascular volume. With sacubitril-valsartan, the antihypertensive effect is additive, and volume depletion may cause symptomatic hypotension or renal function decline.
What this interaction means in plain words
Sacubitril-valsartan and Xipamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive blood pressure lowering through diuresis-induced volume depletion and RAAS/neprilysin inhibition.
What to do
Monitor blood pressure, renal function and electrolytes after starting or adjusting either drug. Consider lowering the diuretic dose if hypotension or volume depletion occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Frequently asked questions
Can I take Sacubitril-valsartan with Xipamide?
MediHelp rates the interaction as moderate. Sacubitril-valsartan and Xipamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Xipamide is a thiazide-like diuretic that lowers blood pressure and intravascular volume. With sacubitril-valsartan, the antihypertensive effect is additive, and volume depletion may cause symptomatic hypotension or renal function decline.
How serious is the interaction between Sacubitril-valsartan and Xipamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and electrolytes after starting or adjusting either drug. Consider lowering the diuretic dose if hypotension or volume depletion occurs.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
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