Drug interactions
Safinamide + Selegiline transdermal
Severity: Contraindicated
Safinamide and Selegiline transdermal: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are MAO inhibitors, and selegiline at antidepressant doses loses MAO-B selectivity. Combining them risks nonselective MAO inhibition with hypertensive crisis and serotonin toxicity.
What this interaction means in plain words
Safinamide and Selegiline transdermal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive MAO inhibition leads to loss of selectivity and accumulation of monoamines.
What to do
Do not combine. Allow at least 14 days between stopping one MAO inhibitor and starting the other.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Safinamide
- Amitriptyline + Safinamide Contraindicated
- Amoxapine + Safinamide Contraindicated
- Amphetamine polistirex + Safinamide Contraindicated
- Clomipramine + Safinamide Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Desipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Safinamide with Selegiline transdermal?
MediHelp rates the interaction as contraindicated. Safinamide and Selegiline transdermal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both are MAO inhibitors, and selegiline at antidepressant doses loses MAO-B selectivity. Combining them risks nonselective MAO inhibition with hypertensive crisis and serotonin toxicity.
How serious is the interaction between Safinamide and Selegiline transdermal?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine. Allow at least 14 days between stopping one MAO inhibitor and starting the other.
What other medicines interact with Safinamide?
MediHelp also lists interactions of Safinamide with, for example, Amitriptyline, Amoxapine, Amphetamine polistirex. The full list is on the Safinamide page.
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