Drug interactions
Safinamide + Sofosbuvir / velpatasvir
Severity: Minor
Safinamide and Sofosbuvir / velpatasvir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sofosbuvir and velpatasvir are BCRP substrates, and safinamide may inhibit intestinal BCRP. Exposure could rise slightly, but this is unlikely to matter given the wide safety margin of these agents.
What this interaction means in plain words
Safinamide and Sofosbuvir / velpatasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of intestinal BCRP efflux by safinamide may increase absorption of the antivirals.
What to do
No dose adjustment is needed. Monitor for antiviral adverse effects such as headache and fatigue.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Safinamide
- Amitriptyline + Safinamide Contraindicated
- Amoxapine + Safinamide Contraindicated
- Amphetamine polistirex + Safinamide Contraindicated
- Clomipramine + Safinamide Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Desipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Safinamide with Sofosbuvir / velpatasvir?
MediHelp rates the interaction as minor. Safinamide and Sofosbuvir / velpatasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sofosbuvir and velpatasvir are BCRP substrates, and safinamide may inhibit intestinal BCRP. Exposure could rise slightly, but this is unlikely to matter given the wide safety margin of these agents.
How serious is the interaction between Safinamide and Sofosbuvir / velpatasvir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor for antiviral adverse effects such as headache and fatigue.
What other medicines interact with Safinamide?
MediHelp also lists interactions of Safinamide with, for example, Amitriptyline, Amoxapine, Amphetamine polistirex. The full list is on the Safinamide page.
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