Drug interactions
Safinamide + Sufentanil sl
Severity: Major
Safinamide and Sufentanil sl: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids with serotonergic activity combined with MAO inhibitors have been associated with serotonin syndrome. Sufentanil has weak serotonergic effects, but the risk with an MAO-B inhibitor cannot be excluded.
What this interaction means in plain words
Safinamide and Sufentanil sl can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
MAO inhibition combined with opioid serotonergic activity may raise serotonin levels; opioid interactions with MAOIs may also cause CNS excitation or depression.
What to do
Avoid the combination where possible and choose an alternative analgesic. If it must be used, monitor for agitation, hyperthermia, clonus and respiratory depression, especially at initiation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Safinamide
- Amitriptyline + Safinamide Contraindicated
- Amoxapine + Safinamide Contraindicated
- Amphetamine polistirex + Safinamide Contraindicated
- Clomipramine + Safinamide Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Desipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Safinamide with Sufentanil sl?
MediHelp rates the interaction as major. Safinamide and Sufentanil sl can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Opioids with serotonergic activity combined with MAO inhibitors have been associated with serotonin syndrome. Sufentanil has weak serotonergic effects, but the risk with an MAO-B inhibitor cannot be excluded.
How serious is the interaction between Safinamide and Sufentanil sl?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and choose an alternative analgesic. If it must be used, monitor for agitation, hyperthermia, clonus and respiratory depression, especially at initiation.
What other medicines interact with Safinamide?
MediHelp also lists interactions of Safinamide with, for example, Amitriptyline, Amoxapine, Amphetamine polistirex. The full list is on the Safinamide page.
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