Drug interactions
Safinamide + Sulfasalazine
Severity: Minor
Safinamide and Sulfasalazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfasalazine is a BCRP substrate, and safinamide may inhibit intestinal BCRP, which may increase sulfasalazine absorption and exposure. The clinical effect is probably small.
What this interaction means in plain words
Safinamide and Sulfasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of intestinal BCRP efflux by safinamide may increase sulfasalazine absorption.
What to do
No dose change is needed. Monitor for sulfasalazine adverse effects such as nausea, rash and blood count changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Safinamide
- Amitriptyline + Safinamide Contraindicated
- Amoxapine + Safinamide Contraindicated
- Amphetamine polistirex + Safinamide Contraindicated
- Clomipramine + Safinamide Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Desipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Safinamide with Sulfasalazine?
MediHelp rates the interaction as minor. Safinamide and Sulfasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sulfasalazine is a BCRP substrate, and safinamide may inhibit intestinal BCRP, which may increase sulfasalazine absorption and exposure. The clinical effect is probably small.
How serious is the interaction between Safinamide and Sulfasalazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed. Monitor for sulfasalazine adverse effects such as nausea, rash and blood count changes.
What other medicines interact with Safinamide?
MediHelp also lists interactions of Safinamide with, for example, Amitriptyline, Amoxapine, Amphetamine polistirex. The full list is on the Safinamide page.
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