Drug interactions
Safinamide + Tenofovir af
Severity: Minor
Safinamide and Tenofovir af: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tenofovir alafenamide is a substrate of intestinal efflux transporters including BCRP. Safinamide may increase its absorption, but the effect is likely small.
What this interaction means in plain words
Safinamide and Tenofovir af have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of intestinal BCRP efflux by safinamide may increase tenofovir alafenamide absorption.
What to do
No dose adjustment is needed. Continue routine renal monitoring for tenofovir therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Safinamide and Tenofovir af, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Safinamide
- Amitriptyline + Safinamide Contraindicated
- Amoxapine + Safinamide Contraindicated
- Amphetamine polistirex + Safinamide Contraindicated
- Clomipramine + Safinamide Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Desipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Safinamide with Tenofovir af?
MediHelp rates the interaction as minor. Safinamide and Tenofovir af have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tenofovir alafenamide is a substrate of intestinal efflux transporters including BCRP. Safinamide may increase its absorption, but the effect is likely small.
How serious is the interaction between Safinamide and Tenofovir af?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Continue routine renal monitoring for tenofovir therapy.
What other medicines interact with Safinamide?
MediHelp also lists interactions of Safinamide with, for example, Amitriptyline, Amoxapine, Amphetamine polistirex. The full list is on the Safinamide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
