Drug interactions
Safinamide + Tenofovir disoproxil
Severity: Minor
Safinamide and Tenofovir disoproxil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Safinamide inhibits BCRP in the gut in vitro, which could slightly raise exposure of BCRP substrates. Tenofovir disoproxil is not a major BCRP substrate, so any effect on tenofovir is likely small and is largely theoretical.
What this interaction means in plain words
Safinamide and Tenofovir disoproxil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible inhibition of intestinal BCRP by safinamide, increasing absorption of substrates.
What to do
No dose change is generally needed. Monitor for tenofovir adverse effects and renal function as part of routine care.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Safinamide
- Amitriptyline + Safinamide Contraindicated
- Amoxapine + Safinamide Contraindicated
- Amphetamine polistirex + Safinamide Contraindicated
- Clomipramine + Safinamide Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Desipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Safinamide with Tenofovir disoproxil?
MediHelp rates the interaction as minor. Safinamide and Tenofovir disoproxil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Safinamide inhibits BCRP in the gut in vitro, which could slightly raise exposure of BCRP substrates. Tenofovir disoproxil is not a major BCRP substrate, so any effect on tenofovir is likely small and is largely theoretical.
How serious is the interaction between Safinamide and Tenofovir disoproxil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed. Monitor for tenofovir adverse effects and renal function as part of routine care.
What other medicines interact with Safinamide?
MediHelp also lists interactions of Safinamide with, for example, Amitriptyline, Amoxapine, Amphetamine polistirex. The full list is on the Safinamide page.
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