Drug interactions
Safinamide + Tyramine
Severity: Moderate
Safinamide and Tyramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Safinamide at recommended doses is a selective MAO-B inhibitor, and a significant tyramine pressor response is uncommon. At higher doses selectivity is lost, and large amounts of tyramine-rich food could cause hypertensive reactions.
What this interaction means in plain words
Safinamide and Tyramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Loss of MAO-B selectivity at higher doses reduces MAO-A metabolism of dietary tyramine, which can potentiate its pressor effect.
What to do
Advise patients to avoid large amounts of tyramine-rich foods such as aged cheeses and cured meats. Do not exceed the recommended safinamide dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Safinamide
- Amitriptyline + Safinamide Contraindicated
- Amoxapine + Safinamide Contraindicated
- Amphetamine polistirex + Safinamide Contraindicated
- Clomipramine + Safinamide Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Desipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Safinamide with Tyramine?
MediHelp rates the interaction as moderate. Safinamide and Tyramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Safinamide at recommended doses is a selective MAO-B inhibitor, and a significant tyramine pressor response is uncommon. At higher doses selectivity is lost, and large amounts of tyramine-rich food could cause hypertensive reactions.
How serious is the interaction between Safinamide and Tyramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid large amounts of tyramine-rich foods such as aged cheeses and cured meats. Do not exceed the recommended safinamide dose.
What other medicines interact with Safinamide?
MediHelp also lists interactions of Safinamide with, for example, Amitriptyline, Amoxapine, Amphetamine polistirex. The full list is on the Safinamide page.
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