Drug interactions
Salbutamol + Selpercatinib
Severity: Moderate
Salbutamol and Selpercatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selpercatinib can prolong the QT interval. Salbutamol may add to arrhythmic risk through hypokalemia and tachycardia, particularly at high doses.
What this interaction means in plain words
Salbutamol and Selpercatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Salbutamol belongs to Respiratory; Selpercatinib belongs to Oncology.
Why it happens
Additive QT prolongation, with beta-2 agonist induced hypokalemia.
What to do
Monitor ECG, potassium and magnesium, and correct abnormalities. Use the lowest effective salbutamol dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salbutamol
Other interactions of Selpercatinib
Frequently asked questions
Can I take Salbutamol with Selpercatinib?
MediHelp rates the interaction as moderate. Salbutamol and Selpercatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selpercatinib can prolong the QT interval. Salbutamol may add to arrhythmic risk through hypokalemia and tachycardia, particularly at high doses.
How serious is the interaction between Salbutamol and Selpercatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG, potassium and magnesium, and correct abnormalities. Use the lowest effective salbutamol dose.
What other medicines interact with Salbutamol?
MediHelp also lists interactions of Salbutamol with, for example, Arsenic trioxide, Carvedilol, Droperidol. The full list is on the Salbutamol page.
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