Drug interactions
Albuterol + Thioridazine
Severity: Major
Albuterol and Thioridazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thioridazine prolongs the QT interval markedly, and albuterol can add to this effect by causing hypokalemia and tachycardia. The combination increases the risk of torsades de pointes.
What this interaction means in plain words
Albuterol and Thioridazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QT prolongation, with beta-2 agonist induced hypokalemia and sympathetic stimulation.
What to do
Use inhaled albuterol only when needed at the lowest effective dose, and check potassium and the QTc. Consider switching from thioridazine to a safer antipsychotic.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Frequently asked questions
Can I take Albuterol with Thioridazine?
MediHelp rates the interaction as major. Albuterol and Thioridazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Thioridazine prolongs the QT interval markedly, and albuterol can add to this effect by causing hypokalemia and tachycardia. The combination increases the risk of torsades de pointes.
How serious is the interaction between Albuterol and Thioridazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use inhaled albuterol only when needed at the lowest effective dose, and check potassium and the QTc. Consider switching from thioridazine to a safer antipsychotic.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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