Drug interactions
Salbutamol + Vandetanib
Severity: Moderate
Salbutamol and Vandetanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vandetanib markedly prolongs the QT interval and can cause torsades de pointes. Salbutamol can add to this through beta-agonist-induced hypokalemia and tachycardia, especially at high or nebulized doses.
What this interaction means in plain words
Salbutamol and Vandetanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Salbutamol belongs to Respiratory; Vandetanib belongs to Oncology.
Why it happens
Additive QT prolongation, with beta-2 agonist-induced hypokalemia and sympathetic stimulation increasing arrhythmic risk.
What to do
Check baseline and follow-up ECG, potassium and magnesium, and correct any deficits. Use the lowest effective salbutamol dose and avoid frequent high-dose use during vandetanib therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salbutamol
Other interactions of Vandetanib
- Amiodarone + Vandetanib Contraindicated
- Amisulpride + Vandetanib Contraindicated
- Amitriptyline + Vandetanib Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Asenapine + Vandetanib Contraindicated
- Chloroquine + Vandetanib Contraindicated
Frequently asked questions
Can I take Salbutamol with Vandetanib?
MediHelp rates the interaction as moderate. Salbutamol and Vandetanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vandetanib markedly prolongs the QT interval and can cause torsades de pointes. Salbutamol can add to this through beta-agonist-induced hypokalemia and tachycardia, especially at high or nebulized doses.
How serious is the interaction between Salbutamol and Vandetanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline and follow-up ECG, potassium and magnesium, and correct any deficits. Use the lowest effective salbutamol dose and avoid frequent high-dose use during vandetanib therapy.
What other medicines interact with Salbutamol?
MediHelp also lists interactions of Salbutamol with, for example, Arsenic trioxide, Carvedilol, Droperidol. The full list is on the Salbutamol page.
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