Drug interactions
Salicylates + Timolol
Severity: Minor
Salicylates and Timolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Regular salicylate use at anti-inflammatory doses may blunt the antihypertensive effect of beta-blockers through prostaglandin inhibition and sodium retention. The effect is mainly relevant with sustained higher-dose use.
What this interaction means in plain words
Salicylates and Timolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of prostaglandin synthesis causes sodium and water retention that opposes the blood pressure lowering of timolol.
What to do
Monitor blood pressure if salicylates are used regularly at analgesic or anti-inflammatory doses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Timolol
- Acebutolol + Timolol Major
- Albuterol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
Frequently asked questions
Can I take Salicylates with Timolol?
MediHelp rates the interaction as minor. Salicylates and Timolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Regular salicylate use at anti-inflammatory doses may blunt the antihypertensive effect of beta-blockers through prostaglandin inhibition and sodium retention. The effect is mainly relevant with sustained higher-dose use.
How serious is the interaction between Salicylates and Timolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure if salicylates are used regularly at analgesic or anti-inflammatory doses.
What other medicines interact with Timolol?
MediHelp also lists interactions of Timolol with, for example, Acebutolol, Albuterol, Aldesleukin. The full list is on the Timolol page.
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