Drug interactions
Salicylates + Tolmetin
Severity: Moderate
Salicylates and Tolmetin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining tolmetin with non-aspirin salicylates increases the risk of gastrointestinal irritation, bleeding and renal impairment without added benefit. Salicylates may also reduce NSAID protein binding and increase adverse effects.
What this interaction means in plain words
Salicylates and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive cyclooxygenase inhibition leading to mucosal injury, platelet dysfunction and reduced renal prostaglandin synthesis.
What to do
Avoid concurrent use and keep to a single NSAID-type agent. If combined, monitor for gastrointestinal bleeding and renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Frequently asked questions
Can I take Salicylates with Tolmetin?
MediHelp rates the interaction as moderate. Salicylates and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining tolmetin with non-aspirin salicylates increases the risk of gastrointestinal irritation, bleeding and renal impairment without added benefit. Salicylates may also reduce NSAID protein binding and increase adverse effects.
How serious is the interaction between Salicylates and Tolmetin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and keep to a single NSAID-type agent. If combined, monitor for gastrointestinal bleeding and renal function.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Tolmetin page.
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