Drug interactions
Salicylates + Trandolapril
Severity: Moderate
Salicylates and Trandolapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Non-acetylsalicylic salicylates given at anti-inflammatory doses may blunt the antihypertensive effect of ACE inhibitors and may reduce renal function, especially in volume-depleted or elderly patients. Effects are usually modest.
What this interaction means in plain words
Salicylates and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of prostaglandin synthesis reduces vasodilation and renal perfusion, opposing ACE inhibitor effects.
What to do
Monitor blood pressure and serum creatinine and potassium when salicylates are used regularly at high doses. Keep patients hydrated and use the lowest effective salicylate dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trandolapril
- Aliskiren + Trandolapril Contraindicated
- Protein a column + Trandolapril Contraindicated
- Sacubitril / valsartan + Trandolapril Contraindicated
- Sacubitril-valsartan + Trandolapril Contraindicated
- Aldesleukin + Trandolapril Major
- Amifostine + Trandolapril Major
Frequently asked questions
Can I take Salicylates with Trandolapril?
MediHelp rates the interaction as moderate. Salicylates and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Non-acetylsalicylic salicylates given at anti-inflammatory doses may blunt the antihypertensive effect of ACE inhibitors and may reduce renal function, especially in volume-depleted or elderly patients. Effects are usually modest.
How serious is the interaction between Salicylates and Trandolapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and serum creatinine and potassium when salicylates are used regularly at high doses. Keep patients hydrated and use the lowest effective salicylate dose.
What other medicines interact with Trandolapril?
MediHelp also lists interactions of Trandolapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Trandolapril page.
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