Drug interactions
Salicylates + Triamterene
Severity: Moderate
Salicylates and Triamterene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At analgesic or anti-inflammatory doses, non-acetylated salicylates can reduce renal prostaglandins and affect renal function. With triamterene this may contribute to hyperkalemia and renal impairment, though the effect is generally less than with other NSAIDs.
What this interaction means in plain words
Salicylates and Triamterene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Salicylate-related inhibition of renal prostaglandins reduces renal perfusion and aldosterone activity, adding to triamterene potassium retention.
What to do
Monitor serum potassium and renal function when using regular high-dose salicylates; avoid in renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Triamterene
- Amiloride + Triamterene Contraindicated
- Eplerenone + Triamterene Contraindicated
- Potassium citrate / citric acid + Triamterene Contraindicated
- Potassium citrate + Triamterene Contraindicated
- Spironolactone + Triamterene Contraindicated
- Aceclofenac + Triamterene Major
Frequently asked questions
Can I take Salicylates with Triamterene?
MediHelp rates the interaction as moderate. Salicylates and Triamterene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. At analgesic or anti-inflammatory doses, non-acetylated salicylates can reduce renal prostaglandins and affect renal function. With triamterene this may contribute to hyperkalemia and renal impairment, though the effect is generally less than with other NSAIDs.
How serious is the interaction between Salicylates and Triamterene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function when using regular high-dose salicylates; avoid in renal impairment.
What other medicines interact with Triamterene?
MediHelp also lists interactions of Triamterene with, for example, Amiloride, Eplerenone, Potassium citrate / citric acid. The full list is on the Triamterene page.
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