Drug interactions
Salicylates + Valsartan
Severity: Moderate
Salicylates and Valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Non-acetylated salicylates have NSAID-like effects that may reduce renal prostaglandins and blunt the effect of valsartan. They may also contribute to renal impairment and hyperkalemia, particularly in volume-depleted or elderly patients.
What this interaction means in plain words
Salicylates and Valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Reduced vasodilatory renal prostaglandin synthesis, causing sodium retention and reduced glomerular perfusion, which opposes ARB effect and risks renal function decline.
What to do
Monitor blood pressure, renal function and potassium, especially with high salicylate doses. Ensure hydration and use the lowest effective dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Valsartan
- Aliskiren + Valsartan Contraindicated
- Sparsentan + Valsartan Contraindicated
- Aldesleukin + Valsartan Major
- Amifostine + Valsartan Major
- Amiloride + Valsartan Major
- Amlodipine-benazepril + Valsartan Major
Frequently asked questions
Can I take Salicylates with Valsartan?
MediHelp rates the interaction as moderate. Salicylates and Valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Non-acetylated salicylates have NSAID-like effects that may reduce renal prostaglandins and blunt the effect of valsartan. They may also contribute to renal impairment and hyperkalemia, particularly in volume-depleted or elderly patients.
How serious is the interaction between Salicylates and Valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and potassium, especially with high salicylate doses. Ensure hydration and use the lowest effective dose.
What other medicines interact with Valsartan?
MediHelp also lists interactions of Valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Valsartan page.
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