Drug interactions
Salmeterol + Thiothixene
Severity: Minor
Salmeterol and Thiothixene: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiothixene is a sedating antipsychotic that can also prolong the QT interval and lower seizure threshold. Salmeterol is a long-acting beta-agonist that has minimal sedative effect and can cause tachycardia and QT prolongation at high exposure. No clinically meaningful sedation interaction is established, but a small additive QT or heart rate effect is conceivable.
What this interaction means in plain words
Salmeterol and Thiothixene have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive cardiac effects (QT prolongation, tachycardia); no established pharmacokinetic interaction.
What to do
No routine change is needed; monitor heart rate and ECG in patients with QT risk factors or cardiac disease.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Frequently asked questions
Can I take Salmeterol with Thiothixene?
MediHelp rates the interaction as minor. Salmeterol and Thiothixene have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiothixene is a sedating antipsychotic that can also prolong the QT interval and lower seizure threshold. Salmeterol is a long-acting beta-agonist that has minimal sedative effect and can cause tachycardia and QT prolongation at high exposure. No clinically meaningful sedation interaction is established, but a small additive QT or heart rate effect is conceivable.
How serious is the interaction between Salmeterol and Thiothixene?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; monitor heart rate and ECG in patients with QT risk factors or cardiac disease.
What other medicines interact with Salmeterol?
MediHelp also lists interactions of Salmeterol with, for example, Ritonavir, Saquinavir, Amitriptyline. The full list is on the Salmeterol page.
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