Drug interactions
Salmeterol + Trifluoperazine
Severity: Moderate
Salmeterol and Trifluoperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trifluoperazine is a phenothiazine antipsychotic that can prolong the QT interval. Salmeterol can also cause tachycardia, hypokalemia and QT prolongation, particularly at high doses or with excess use. Combining them may modestly increase the risk of arrhythmia in susceptible patients.
What this interaction means in plain words
Salmeterol and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation and possible beta-agonist-induced hypokalemia.
What to do
Monitor ECG and serum potassium in patients with cardiac disease, electrolyte disturbance or other QT-prolonging drugs, and avoid exceeding the labeled salmeterol dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Salmeterol and Trifluoperazine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Frequently asked questions
Can I take Salmeterol with Trifluoperazine?
MediHelp rates the interaction as moderate. Salmeterol and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trifluoperazine is a phenothiazine antipsychotic that can prolong the QT interval. Salmeterol can also cause tachycardia, hypokalemia and QT prolongation, particularly at high doses or with excess use. Combining them may modestly increase the risk of arrhythmia in susceptible patients.
How serious is the interaction between Salmeterol and Trifluoperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and serum potassium in patients with cardiac disease, electrolyte disturbance or other QT-prolonging drugs, and avoid exceeding the labeled salmeterol dose.
What other medicines interact with Salmeterol?
MediHelp also lists interactions of Salmeterol with, for example, Ritonavir, Saquinavir, Amitriptyline. The full list is on the Salmeterol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
