Drug interactions
Salmeterol + Yohimbine
Severity: Moderate
Salmeterol and Yohimbine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yohimbine is an alpha-2 antagonist that increases noradrenergic outflow, raising blood pressure and heart rate. Salmeterol adds beta-adrenergic stimulation with tachycardia and palpitations. Together they may produce additive sympathomimetic effects, which matters in hypertension or heart disease.
What this interaction means in plain words
Salmeterol and Yohimbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic sympathetic stimulation (alpha-2 blockade plus beta-2 agonism).
What to do
Monitor blood pressure and heart rate, and avoid the combination in patients with uncontrolled hypertension or arrhythmias.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Frequently asked questions
Can I take Salmeterol with Yohimbine?
MediHelp rates the interaction as moderate. Salmeterol and Yohimbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Yohimbine is an alpha-2 antagonist that increases noradrenergic outflow, raising blood pressure and heart rate. Salmeterol adds beta-adrenergic stimulation with tachycardia and palpitations. Together they may produce additive sympathomimetic effects, which matters in hypertension or heart disease.
How serious is the interaction between Salmeterol and Yohimbine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, and avoid the combination in patients with uncontrolled hypertension or arrhythmias.
What other medicines interact with Salmeterol?
MediHelp also lists interactions of Salmeterol with, for example, Ritonavir, Saquinavir, Amitriptyline. The full list is on the Salmeterol page.
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