Drug interactions
Salsalate + Timolol
Severity: Minor
Salsalate and Timolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salsalate is a salicylate NSAID that may reduce the blood pressure lowering effect of timolol during prolonged use. It can also affect renal function in susceptible patients.
What this interaction means in plain words
Salsalate and Timolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Prostaglandin synthesis inhibition leads to fluid retention that antagonizes the antihypertensive effect of timolol.
What to do
Monitor blood pressure if salsalate is taken regularly, and reassess the antihypertensive regimen if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Timolol
- Acebutolol + Timolol Major
- Albuterol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
Frequently asked questions
Can I take Salsalate with Timolol?
MediHelp rates the interaction as minor. Salsalate and Timolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Salsalate is a salicylate NSAID that may reduce the blood pressure lowering effect of timolol during prolonged use. It can also affect renal function in susceptible patients.
How serious is the interaction between Salsalate and Timolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure if salsalate is taken regularly, and reassess the antihypertensive regimen if control worsens.
What other medicines interact with Timolol?
MediHelp also lists interactions of Timolol with, for example, Acebutolol, Albuterol, Aldesleukin. The full list is on the Timolol page.
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