Drug interactions
Salsalate + Tobramycin
Severity: Moderate
Salsalate and Tobramycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salsalate, a salicylate NSAID, may reduce renal clearance of tobramycin and raise its serum concentrations. This increases the risk of nephrotoxicity and ototoxicity, particularly in neonates or patients with impaired kidney function.
What this interaction means in plain words
Salsalate and Tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of renal prostaglandins reduces renal perfusion and tobramycin clearance.
What to do
Monitor serum creatinine and tobramycin concentrations during co-therapy, and adjust the tobramycin dose accordingly. Use a non-NSAID analgesic if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tobramycin
- Cidofovir + Tobramycin Contraindicated
- Adefovir + Tobramycin Major
- Amikacin + Tobramycin Major
- Amphotericin b deoxycholate + Tobramycin Major
- Amphotericin b + Tobramycin Major
- Atracurium + Tobramycin Major
Frequently asked questions
Can I take Salsalate with Tobramycin?
MediHelp rates the interaction as moderate. Salsalate and Tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salsalate, a salicylate NSAID, may reduce renal clearance of tobramycin and raise its serum concentrations. This increases the risk of nephrotoxicity and ototoxicity, particularly in neonates or patients with impaired kidney function.
How serious is the interaction between Salsalate and Tobramycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and tobramycin concentrations during co-therapy, and adjust the tobramycin dose accordingly. Use a non-NSAID analgesic if feasible.
What other medicines interact with Tobramycin?
MediHelp also lists interactions of Tobramycin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Tobramycin page.
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