Drug interactions
Salsalate + Tolmetin
Severity: Moderate
Salsalate and Tolmetin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salsalate is a salicylate NSAID, so combining it with tolmetin duplicates therapy and increases the risk of gastrointestinal bleeding, renal injury and hyperkalemia. There is no added analgesic benefit.
What this interaction means in plain words
Salsalate and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive cyclooxygenase inhibition causing gastric mucosal injury, platelet effects and decreased renal prostaglandins.
What to do
Avoid using both together and select one agent. If unavoidable, monitor for bleeding and check renal function and potassium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Frequently asked questions
Can I take Salsalate with Tolmetin?
MediHelp rates the interaction as moderate. Salsalate and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salsalate is a salicylate NSAID, so combining it with tolmetin duplicates therapy and increases the risk of gastrointestinal bleeding, renal injury and hyperkalemia. There is no added analgesic benefit.
How serious is the interaction between Salsalate and Tolmetin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using both together and select one agent. If unavoidable, monitor for bleeding and check renal function and potassium.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Tolmetin page.
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