Drug interactions
Salsalate + Triamterene
Severity: Moderate
Salsalate and Triamterene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salsalate is a non-acetylated salicylate that can influence renal prostaglandins and renal function at higher doses. With triamterene it may add to the risk of hyperkalemia and kidney injury, although the effect is generally modest.
What this interaction means in plain words
Salsalate and Triamterene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Prostaglandin inhibition reduces renal perfusion and aldosterone activity, adding to triamterene potassium retention.
What to do
Monitor serum potassium and creatinine during regular use, and avoid in patients with renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Triamterene
- Amiloride + Triamterene Contraindicated
- Eplerenone + Triamterene Contraindicated
- Potassium citrate / citric acid + Triamterene Contraindicated
- Potassium citrate + Triamterene Contraindicated
- Spironolactone + Triamterene Contraindicated
- Aceclofenac + Triamterene Major
Frequently asked questions
Can I take Salsalate with Triamterene?
MediHelp rates the interaction as moderate. Salsalate and Triamterene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salsalate is a non-acetylated salicylate that can influence renal prostaglandins and renal function at higher doses. With triamterene it may add to the risk of hyperkalemia and kidney injury, although the effect is generally modest.
How serious is the interaction between Salsalate and Triamterene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and creatinine during regular use, and avoid in patients with renal impairment.
What other medicines interact with Triamterene?
MediHelp also lists interactions of Triamterene with, for example, Amiloride, Eplerenone, Potassium citrate / citric acid. The full list is on the Triamterene page.
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