Drug interactions
Same + Selegiline
Severity: Major
Same and Selegiline: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
SAMe may increase serotonergic activity, and combined with an MAO inhibitor it carries a risk of serotonin syndrome. Agitation, tremor, hyperthermia and autonomic instability may occur.
What this interaction means in plain words
Same and Selegiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive serotonergic effects through increased serotonin availability.
What to do
Avoid combining SAMe with selegiline. If used together, monitor for serotonin toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Frequently asked questions
Can I take Same with Selegiline?
MediHelp rates the interaction as major. Same and Selegiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. SAMe may increase serotonergic activity, and combined with an MAO inhibitor it carries a risk of serotonin syndrome. Agitation, tremor, hyperthermia and autonomic instability may occur.
How serious is the interaction between Same and Selegiline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining SAMe with selegiline. If used together, monitor for serotonin toxicity.
What other medicines interact with Selegiline?
MediHelp also lists interactions of Selegiline with, for example, Amitriptyline, Amoxapine, Atomoxetine. The full list is on the Selegiline page.
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