Drug interactions
Sapropterin + Sildenafil
Severity: Minor
Sapropterin and Sildenafil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sapropterin can promote nitric oxide synthesis, and sildenafil enhances nitric oxide signalling, so additive vasodilation is theoretically possible. This could lower blood pressure, although clinically significant effects have not been well documented.
What this interaction means in plain words
Sapropterin and Sildenafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Sapropterin belongs to Miscellaneous; Sildenafil belongs to Genitourinary.
Why it happens
Additive vasodilation through enhanced nitric oxide synthesis (sapropterin) and cGMP preservation (sildenafil).
What to do
Monitor blood pressure and ask about dizziness when starting the combination; counsel patients to rise slowly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sildenafil
- Amyl nitrite + Sildenafil Contraindicated
- Atazanavir + Sildenafil Contraindicated
- Cobicistat + Sildenafil Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Sildenafil Contraindicated
- Glyceryl trinitrate pr + Sildenafil Contraindicated
- Isosorbide dinitrate + Sildenafil Contraindicated
Other interactions of Sapropterin
- Avanafil + Sapropterin Moderate
- Carbidopa-entacapone-levodopa + Sapropterin Moderate
- Carbidopa-levodopa + Sapropterin Moderate
- Levodopa + Sapropterin Moderate
- Methotrexate + Sapropterin Moderate
- Phenobarbitone + Sapropterin Moderate
Frequently asked questions
Can I take Sapropterin with Sildenafil?
MediHelp rates the interaction as minor. Sapropterin and Sildenafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sapropterin can promote nitric oxide synthesis, and sildenafil enhances nitric oxide signalling, so additive vasodilation is theoretically possible. This could lower blood pressure, although clinically significant effects have not been well documented.
How serious is the interaction between Sapropterin and Sildenafil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and ask about dizziness when starting the combination; counsel patients to rise slowly.
What other medicines interact with Sildenafil?
MediHelp also lists interactions of Sildenafil with, for example, Amyl nitrite, Atazanavir, Cobicistat. The full list is on the Sildenafil page.
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